Hyaluronic acid was first obtained by Karl Meyer and John Palmer in 1934 from the vitreous body in a cow's eye. The first hyaluronan biomedical product, Healon, was developed in the 1970s and 1980s by Pharmacia, and approved for use in eye surgery (i.e., corneal transplantation, cataract surgery, glaucoma surgery, and surgery to repair retinal detachment). Other biomedical companies also produce brands of hyaluronan for ophthalmic surgery.Native hyaluronic acid has a relatively short half-life (shown in rabbits) so various manufacturing techniques have been deployed to extend the length of the chain and stabilize the molecule for its use in medical applications. The introduction of protein-based cross-links, the introduction of free-radical scavenging molecules such as sorbitol, and minimal stabilization of the HA chains through chemical agents such as NASHA (non-animal stabilized hyaluronic acid) are all techniques that have been used to preserve its shelf life. In the late 1970s, intraocular lens implantation was often followed by severe corneal edema, due to endothelial cell damage during the surgery. It was evident that a viscous, clear, physiologic lubricant to prevent such scraping of the endothelial cells was needed. The name "hyaluronan" is also used for a salt. (Wikipedia)

6. Increased Resilience-

When the lipid barrier is further enhanced and protected by hyaluronic acid, the skin is better able to defend itself against environmental age-factors and pollutants. When it’s not fighting these toxins, the skin remains less wrinkled, brighter, and bouncier longer.

A good tip to remember preservatives used in a lot of products can break down your barrier by killing off the good bacteria that also defend the surface of your skin against toxins. The result is a loss of moisture, as well as potential irritation and even infection. A lot of people with oily skin want to apply harsher chemicals to “strip” the skin of oil. It’s important to know that most acne-prone skin doesn’t have a strong lipid barrier, which encourages inflammation and irritation. Hyaluronic adds hydration, helps protect the lipid barrier, and is recommended for those with sensitive or acne-prone skin.

7. Less Visible Fine Lines and Wrinkles-

 It’s never too early to start protecting and nourishing the skin. Hyaluronic acid is truly an ingredient that gives benefits to twenty to eighty year old skin.

Hyaluronic Acid helps reduce the visibility of fine lines and wrinkles retaining moisture to the skin, creating a plumping effect. When the skin is protected and hydrated, increased skin cell production can take place, as the skin isn’t busy fighting for hydration. This leads to smoother, plumper skin cells.

8. Anti-aging-

Around 50%Trusted Source (Mariko Oe, 2017)of the body’s total hyaluronic acid is present in the skin. Changes in this amount, possibly due to UV exposure, can lead to the formation of wrinkles.

Hyaluronic acid can significantly decrease the depth of wrinkles and enhance skin firmness and elasticity.

One 2014 study Trusted Source (S. Manjula Jegasothy, Efficacy of a New Topical Nano-hyaluronic Acid in Humans, 2014) involved women applying hyaluronic acid topically, twice daily, for 8 weeks.

The study reported up to a 40% decrease in the depth of wrinkles and an up to 55% increase in skin firmness and elasticity compared with participants who did not apply the acid.

1.Smoother Texture:

Much, in the same way, it makes the appearance of the skin look tighter, hyaluronic acid also smoothes the texture of the skin. This results in a silky-smooth finish you can see and feel.

If the skin is visibly scarred from acne, hyaluronic acid will not fill in those scars. But, combined with a tool like a dermatoller, over time, hyaluronic acid plus a derma roller can make skin look smoother.

2.Pigmentation:

when there is increased cell turnover, hyaluronic acid also helps reduce and prevent age spots and pigmentation issues. But it cannot do it on its own. When looking to treat dark spots, a vitamin c serum and vitamin c booster product should be paired with hyaluronic acid.

Also, no amount of sun damage can be undone without first protecting the skin from future sun damage. Always wear an SPF of at least 30 on a daily basis. Even the days you don’t plan to be outside.

1. Preserve bone strength:

New animal research has begun to investigate the effects of hyaluronic acid supplements on bone health.

Two older studies have found that hyaluronic acid supplements can help slow the rate of bone loss in rats with osteopenia, the beginning stage of bone loss that precedes osteoporosis (M Stancíková 1, 2004) (Jenny Ma 1, 2013).

Some older test-tube studies have also shown that high doses of hyaluronic acid can increase the activity of osteoblasts, the cells responsible for building new bone tissue (L Huang 1, 2003) (Daniel Lajeunesse 1, 2003)

While more high quality, recent research in humans is needed, early animal and test-tube studies are promising.

2. Soothe acid reflux symptoms:

Gastroesophageal reflux disease (GERD) is a common condition that causes symptoms such as acid reflux and heartburn.

One 2017 trial Trusted Source (V. Savarino, 2017) found that hyaluronic acid supplements taken with acid suppression helped to improve symptoms of people with non-erosive reflux disease, a type of GERD.

3. Relieve joint pain by keeping bones lubricated:

A person can receive injections into the joints to help lubricate them.

One 2017 review Trusted Source (Thippaporn Euppayo, 2017)involved different treatment combinations for people with osteoarthritis who experience joint pain and inflammation.

The study showed that combining hyaluronic acid with medications used for treating these symptoms, such as non-steroidal anti-inflammatory drugs or corticosteroids, can increase how effectively these treatments work.

4. Treats vaginal dryness:

Vaginal dryness often affects females following menopause. It can affect a person’s quality of life.

One 2016 study Trusted Source (Azam Jokar, 2016) found that a combination of hyaluronic acid cream and an estrogen cream helped to alleviate symptoms of vaginal dryness.

Researchers also noted that hyaluronic acid was the more effective of the two. So, people who cannot use hormonal treatment, such as estrogen cream, could use hyaluronic acid alone to help ease symptoms.

5. Combats gum disease:

One 2016 systematic review Trusted Source (Manuele Casale 1, 2016) suggested that topical hyaluronic acid may play a pivotal role in the postoperative care of people undergoing dental procedures.

Hyaluronic acid can help heal wounds. It can also have positive impacts on people with gum disease and mouth ulcers.

6. Prevents bladder pain:

There is some evidence (W.J.b, 2016) that introducing hyaluronic acid into the bladder through a catheter may help alleviate some of the symptoms of painful bladder syndrome.

However, no evidence indicates whether oral supplements would produce enough hyaluronic acid in the bladder to have any impact.

There are many ways you can take hyaluronic acid (either on its own or in combination products). Many are available over the counter. Some need a doctor’s prescription. For some, you need to see a trained medical professional. (Hyaluronic Acid)

A few of the different ways (available over the counter) that you can take hyaluronic acid include:

• By mouth:Hyaluronic acid comes in dietary supplements and pills. There’s even a liquid form that you can mix with water and drink.
  • Taking hyaluronic acid by mouth can have many benefits. These include reducing arthritis pain, improving skin health and more.

• By injection: Hyaluronic acid injections into your joints can relieve pain caused by arthritis. It’s also commonly used with medications given in an IV. Healthcare providers may prescribe it off-label to treat bladder pain (such as pain caused by interstitial cystitis).
• Under your skin: Fillers containing hyaluronic acid and collagen (a natural protein also found in your body) are approved for injection under your skin. These fillers help restore natural shape and appearance, such as for treating acne scars or adding volume to lips.
• In your nose: Some medications use hyaluronic acid because it helps your body absorb them, especially when taken through your nose.
• By inhaler/nebulizer: Hyaluronic acid can treat respiratory (breathing) problems such as asthma or infections.

Remember, only trained and qualified medical professionals should give injections. While experts say hyaluronic acid is safe, improper use — especially when injecting it — can lead to severe complications or even death.

• How does hyaluronic acid work?

A. Hyaluronic acid belongs to a type of long, complicated chain-like molecules called polymers. The chain has plenty of spots on it where other chemical compounds (like water, for example) can latch on. That’s why a quarter teaspoon of hyaluronic acid can hold about one and a half gallons of water, making it the best polymer — natural or artificial — for absorbing water (and a key ingredient in moisturizing products).

Because it has lots of space for other molecules to latch on, hyaluronic acid is great for transporting other molecules throughout your body. It also has the ability to attach itself to cells, which is why targeted delivery of medications using hyaluronic acid is a major topic of study.Hyaluronic acid’s chain-like structure also means it can act like a scaffold structure, allowing tissues to grow. This is a key step in how wounds heal on your body. Scientists have also found hyaluronic acid in human embryos and are studying what role hyaluronic acid plays in reproduction and development.

Q. Does hyaluronic acid work?

A. Yes, depending on how it’s used. It’s a versatile molecule and scientists are still finding new and beneficial ways to use it. Right now, it’s most often used for skin, joint and eye health. It’s also the topic of hundreds of scientific studies and trials around the world.

Q. What does hyaluronic acid do for skin?

A. Long-term use of hyaluronic acid serum on your skin or in a supplement taken by mouth can improve overall skin health. It’s also great for helping improve overall skin flexibility and elasticity (meaning it makes your skin more stretchy and soft).

Q. Is hyaluronic acid good for acne?

A. Hyaluronic acid is widely used as an ingredient in fillers that repair or conceal scars left behind by acne. There has been some limited research into combinations of hyaluronic acid and other medications to treat acne, but so far, there isn’t much evidence that these are effective.

Q. Is hyaluronic acid safe?

A. Yes, depending on how it’s used. Over-the-counter hyaluronic acid serums and products applied on your skin (creams, lotions, etc.) or in eye care products are considered safe. Hyaluronic acid supplements taken by mouth are also considered safe (but you should still tell your healthcare provider about them, as you would for any other medication, vitamin or supplement).

Prescription hyaluronic acid products should be taken exactly as instructed by your healthcare provider. Injections of any kind containing hyaluronic acid should only be given by a licensed, qualified medical professional.

Q. When should I talk to my healthcare provider about hyaluronic acid?

A. You may want to talk to your healthcare provider about hyaluronic acid if you’re interested in using it as a supplement. You may also want to also ask them about treatment options that use hyaluronic acid for the following conditions or purposes:

• Skin health (especially dryness, scarring, stiffness and skin diseases like scleroderma and actinic keratosis).
• Eye health, especially for treating dry eyes.
• Joint health, especially for treating arthritis and soft tissue injuries.
• For wounds that are slow to heal.
• As a treatment option for bladder pain, especially pain caused by interstitial cystitis.
• Respiratory conditions like asthma.

When to Use Hyaluronic Acid Serum?

A. As discussed, hyaluronic acid (also known as hyaluronan or HA) is a molecule naturally produced by the human body. Most of the body’s hyaluronic acid deposits are found inside the skin, though there are also deposits found along the joints and cartilages on the bones.

The primary role of hyaluronic acid is to help the skin hold on to water, hydrating the outer layers and preventing dry skin from happening. Dry skin is one of the usual culprits behind damaged skin since it breaks down the skin’s structure and makes it more likely to be damaged by things like the sun and other outside factors.

If a patient is looking to treat dry skin, repair any skin damage, or basically improve the appearance of their skin overall, hyaluronic acid is an excellent product to use. It’s extremely rare to experience any side effects from HA since it’s a natural ingredient that’s produced by the body and is found everywhere in the body. It’s also an extremely effective antioxidant.

A particular benefit that hyaluronic acid can confer is the ability to speed up wound healing. It does this by encouraging blood vessels to form in damaged areas of the skin, which helps bring nutrients and other compounds needed for skin regrowth. It also helps by reducing inflamed blood vessels, which can help with pain relief. As an antioxidant, it also helps by managing the free radicals in the skin cells, protecting it from damage. It protects the skin against sun damage, though it should not be used as a substitute for sunscreen.

Because it’s naturally found inside the human body in large concentrations, hyaluronic acid can be taken by anyone. Any side effects experienced will most likely be a reaction to other compounds in the HA product; for this reason, it’s best to consult a dermatologist about the exact brands that patients should buy.

Q. What do Dermatologist say about hyaluronic acid? 

A. Hyaluronic acid is a skin care staple for plump, hydrated skin, dermatologists say. Hyaluronic acid is a “great hydrator for pretty much all skin types,” one expert said.

Q. What is the drug hyaluronic acid used for?

A. Descriptions. Hyaluronic acid injection is used to treat knee pain caused by osteoarthritis (OA) in patients who have already been treated with pain relievers (e.g., acetaminophen) and other treatments that did not work well.

Q. What happens if you use hyaluronic acid everyday?

• "Hyaluronic acid is safe and beneficial to use everyday for maintaining skin hydration," says Dr. Russak. You just need to make sure you're applying it correctly. As a rule, you want to apply your hyaluronic acid product to clean, damp skin, and the lock it in with a moisturizer and face oil.

Q. What are the three types of hyaluronic acid?

• It comes with three different types of HA, including hydrolyzed hyaluronic acid, sodium acetylated hyaluronate, and sodium hyaluronate.

Q. What is hyaluronic acid on an ingredient list?

A. In cosmetics, Hyaluronic Acid is mainly used as a humectant and thickener. A humectant is an ingredient that can absorb and keep a lot of moisture. These ingredients are ideal when trying to maintain our skin's natural moisture.

Q. Does hyaluronic acid brighten skin?

• Products formulated with hyaluronic acid can also brighten skin's appearance. Skin will appear glowy and smoother after use.

Q. Can I leave hyaluronic acid on my face overnight?

A. It's always best to follow specific product instructions and to start off slowly. Generally, though, you can safely use hyaluronic acid both morning and night.

Q. Can hyaluronic acid remove dark spots?

A. Reduces spots –
Hyaluronic acid helps reduce and prevent dark spots and pigmentation. It prevents your skin from damage caused by the sun and other external aggressors such as dust, pollution and more by acting as a protective barrier to your skin.

Q. How soon do you see results from hyaluronic acid?

• Most people who take hyaluronic acid every day in the right dosage see results (such as the improvement of skin elasticity and reduction of skin roughness) in 4-8 weeks. However, everybody is different and some may see results in as little as 2-4 weeks.

Q. Does hyaluronic acid reverse aging?

A. Hyaluronic acid has beneficial properties when used on your skin. It's especially useful for reducing the appearance of wrinkles and age lines.

Q. How hyaluronic acid changed my skin?

A. Hyaluronic acid plumps your skin, making it bouncy and supple. Dermatologists use gel-form hyaluronic acid in injectables to decrease fine lines. Hyaluronic acid can retain 1000X its weight in water, locking in moisture to your skin, which gives it a dewy shine.

Q. Which is better collagen or hyaluronic acid?

A. For topical products, hyaluronic acid is the clear winner. Building collagen takes time and other methods, but it will give you the most long-term and visible results to prevent wrinkles and improve skin elasticity and strength overall.

Q. Does hyaluronic acid rebuild collagen?

A. One study suggests that hyaluronic acid can help boost collagen production in the human body. Hyaluronic acid is naturally found in the body, but it decreases as we age. Eating foods rich in vitamin C and amino acids can increase the levels of hyaluronic acid and collagen in the body as both are important for skin.

Q. What not to mix with hyaluronic acid?

A. “Hyaluronic acid plays well with most ingredients, while caution must be taken when using retinol in combination with alpha hydroxy and beta hydroxy acids, benzoyl peroxide, and some types of vitamin C.” Linkner echoes the tip about avoiding vitamin C.

Q. Does hyaluronic acid tighten skin?

A. Hyaluronic Acid is NOT going to replace your elastin but, it can help with the appearance of tightness in the skin. As it fills the skin with moisture, hyaluronic acid tightens the overall complexion. It helps firm facial contours for a more youthful appearance.

Q. What is the best way to absorb hyaluronic acid?

A. Moisturizers and serums are two of the most common forms of hyaluronic acid. Moisturizers. Use a moisturizer infused with hyaluronic acid at the time when you'd usually moisturize. Ideally, this would be 2 times a day and always after cleansing, exfoliating, or applying serums.

Q. What are the 5 types of hyaluronic acid?

A. “Sodium Hyaluronate”, “Hyaluronic acid”, “Hydrolyzed hyaluronic acid”, “Sodium Hyaluronate Crosspolymer”, “Sodium Acetylated Hyaluronate” it can be difficult to find your way around all these forms of hyaluronic acid.

Q. Can I rub hyaluronic acid on my face?

A. Apply hyaluronic acid serum to a damp face.
If you're using a hyaluronic acid serum, use it after you wash your face with cleanser and/or toner. Don't dry your face after cleansing or toning. Apply a couple of drops of hyaluronic acid serum to your damp face and rub in.

Q. Does hyaluronic acid make your face glow?

A. As an ingredient in skin care, hyaluronic acid is a powerful humectant which means it draws moisture from the environment into the skin for increased hydration, resulting in a plump, luminous and glowing complexion. Hyaluronic acid also replenishes the skin to help decrease the look of fine lines and wrinkles.

Q. Do you put moisturizer after hyaluronic acid?

A. The way you want to use hyaluronic acid in a skincare routine is to start by cleansing your face with a nice simple cleanser. And then, with slightly damp skin or even slightly wet skin, apply the hyaluronic acid serum to your face followed by a moisturizer and sunscreen (during the day).

Q. When should I start using hyaluronic acid?

A. Signs you need it: When you start seeing fine lines under your eyes. At a young age, these might suggest dehydration. Hyaluronic acid is a naturally occurring polysaccharide found in the human body.

Q. What are the negative side effects of hyaluronic acid?

A. The most common adverse effects associated with hyaluronic acid filler are pain, bruising, redness, itching, and swelling. These side effects are self-limited and typically last no more than seven days.

Q. What are the long-term effects of hyaluronic acid?

A. Long-term use of hyaluronic acid serum on your skin or in a supplement taken by mouth can improve overall skin health. It's also great for helping improve overall skin flexibility and elasticity (meaning it makes your skin more stretchy and soft).

Q. Can I use hyaluronic acid alone without moisturizer?

A. The ingredient needs to be used in conjunction with other moisturizers; hyaluronic acid alone will not provide the necessary hydration skin needs. "It's really meant as a temporary hydrator, when applied to damp skin," Dr. Shamban says. "If your skin is already dry, you could actually be doing more harm than good."

Q. Why is my skin peeling after hyaluronic acid?

A. Certain ingredients like Hyaluronic Acid, if used as a standalone ingredient then it can harm your skin since it is a Humectant that will draw moisture from the environment and if there is none in the air then it will draw moisture from the deepest layer of your skin which makes it extremely drying to the skin.

Q. Does hyaluronic acid regenerate skin?

A. Hyaluronic acid is remarkable in regenerating the skin and in stimulating collagen efficacy. In addition to moisturizing, hyaluronic acid rejuvenates the skin without adding an added layer of oil or grease. While it rejuvenates, it also contours and nourishes the face.

Q. What does hyaluronic acid do to the brain?

A. Hyaluronic acid (HA) is a primary component of the brain extracellular matrix and functions through cellular receptors to regulate cell behavior within the central nervous system (CNS).

Q. Is hyaluronic acid actually good for skin?

A. Hyaluronic acid helps skin stretch and flex and reduces skin wrinkles and lines. Hyaluronic acid is also proven to help wounds heal faster and can reduce scarring.

Q. What's better retinol or hyaluronic acid?

A. Hyaluronic acid is best if they're looking to moisturize dry skin, while retinol works better by encouraging better skin by boosting collagen production. They have several benefits that can work in tandem for better results, though patients need to be careful with the exact formulations they use.

Q. What percentage of hyaluronic acid is effective for skin?

A. 2%, But when a hyaluronic acid serum is a well-balanced concentration, it uses the water molecules from the serum, holding them in place so that your skin is hydrated — and you look amazing. The percentage of hyaluronic acid to look for in a serum is just over 2%.

Q. Is hyaluronic acid safe to use for sensitive skin?

A. We’re happy to report that hyaluronic acid is completely safe to use for those with dry and sensitive skin since it’s gentle and is also found naturally in our bodies.

Q. Is there any way to make even more out of hyaluronic acid?

A. While hyaluronic acid is a superstar ingredient on its own, you can reap even more benefits from it by using it along with other ingredients! The good news here is that it basically gets along with everyone –– so you can use it along with vitamin C, niacinamide, ceramides, and yes, even retinol!

Q. What are the dangers of hyaluronic acid?

A. Hyaluronic acid is generally safe to be used on all skin types and has very few reported side effects. Since it is a naturally occurring substance found in the body, allergic reactions are very rare. Just make sure to use it in the right formulation.

Q. Is hyaluronic acid good for pimples?

A. Hyaluronic acid is effective in controlling sebum production, which makes it a potentially useful ingredient for acne prevention. It is also effective in reducing the redness of pimples and diminishing acne scars.