• Caffeine is consumed in beverages and foods.  It's most known as an ingredient in coffee, green and black tea, and chocolate. It's also added to some foods to give them extra flavor or energy. (Völker et al., 2020)  

• Caffeine is a naturally occurring methylxanthine alkaloid with special properties, making it useful for skin care and treating skin problems. (Visconti, Haidari and Feldman, 2020) 

• Caffeine's numerous effects at the cellular level have potential applications in the treatment of disorders related to the skin and hair. (Visconti, Haidari and Feldman, 2020) 

• Caffeine's easy penetration across the skin barrier and into human skin makes it an ideal compound for topical application.  (Völker et al., 2020)  

• A natural ingredient, Caffeine, is a promising alternative for developing topical treatments to help reduce male pattern hair loss (androgenetic alopecia). Where a few approved drugs are available to treat androgenetic alopecia, they often come with side effects.  (Völker et al., 2020)  

• Research said that males and females with AGA confirmed that hair loss is reduced using caffeine-containing topical formulations.  (Völker et al., 2020)

• Caffeine can inhibit the activity of the 5-α-reductase enzyme that plays an essential role in hair loss and allows a renewed growth phase of the hair. (Bussoletti, Tolaini and Celleno, 2018)

• Caffeine is used in body care products for its anti-cellulite effects. (Blanco-Llamero et al., 2024)

• Caffeine boosts blood microcirculation, which may help reduce dark circles and puffiness under the eyes. (Amnuaikit, Maneenuan and Boonme, 2011) 

• Caffeine is known for its antioxidant properties and is commonly found in moisturising creams and anti-aging cosmetics. (Blanco-Llamero et al., 2024) 

• Caffeine can enhance the sunscreen scattering effect of well-known ultraviolet (UV) blockers. (Blanco-Llamero et al., 2024) 

• Caffeine is rapidly and completely absorbed after ingestion. It crosses cell membranes, including the blood-brain barrier, and distributes throughout the body. (Völker et al., 2020)  

• Caffeine works as a natural insect and weed repellent. Besides being found in nature, caffeine can also be made in factories. (Szendzielorz and Spiewak, 2025)

Coffee beans from two main types of plants—Coffea arabica (Arabica) and Coffea canephora (Robusta)—contain over 2,000 different substances. One of the most well-known is caffeine, which makes up about 1.3% to 2.4% of the bean’s weight. 

It’s important to understand that caffeine and coffee are different. While caffeine is just one active ingredient, coffee contains many other compounds that can affect the body. Caffeine works in the brain and other tissues, influencing important cell functions.

Caffeine is a natural compound found in seeds, leaves, and fruits of more than 60 plant species from Africa, South America, and East Asia. It belongs to a group of chemicals called purine alkaloids and has three methyl groups attached to it. In plants, caffeine works as a natural insect and weed repellent. Besides being found in nature, caffeine can also be made in factories. (Szendzielorz and Spiewak, 2025)

Caffeine was first isolated from coffee in 1819 by the German chemist Friedlieb Ferdinand Runge. In its pure form, caffeine is a white, odorless solid that melts at around 235–238°C. It is a weak base and doesn’t dissolve well in cold water, but it dissolves much better in hot water. (Gupta and Maurya, 2023) 

But it also affects other parts of the body, including the skin. Caffeine may help improve blood flow & reduce inflammation in the skin, which is why it’s being studied for use in hair and skincare products. 

In recent years, caffeine has become popular in cosmetics, especially for its potential to help prevent hair loss and support hair growth. (Szendzielorz and Spiewak, 2025)

Caffeine is a natural chemical in many plants' leaves, seeds, and fruits. It acts as a stimulant, helping people feel more awake and alert. Chemically, caffeine is known as 1,3,7-trimethylxanthine and has the formula C₈H₁₀N₄O₂. It belongs to a group of compounds called alkaloids, which contain nitrogen in their ring structures.

Caffeine is part of a group of chemicals called methylxanthines, including theobromine and theophylline, compounds in tea, chocolate, and other foods and drinks. These substances stimulate the stimulating effects of popular beverages like coffee, tea, and cola. (Gupta and Maurya, 2023)

• Systematic name – 1, 3, 7 – trimethyl – 1H – purine – 2, 6 (3H, 7H) - Dione 

• Other names – 1, 3, – 7-trimethylxanthine and 1, 3, 7–trimethyl–2, 6-dioxopurine 

• Molecular formula – C8H10N4O2 

• Molecular mass – 194.19 g/mole 

• Melting point – 238° C 

• Solubility in water – slightly soluble 

• Caffeine stimulates the central nervous system and the action of the heart and lungs.

• It increases blood pressure and promotes urine formation. (Gupta and Maurya, 2023)

Caffeine is well known for giving energy, but it has many other uses. It can help the brain and heart work better, and it's used in many products like medicines and beauty creams. In skincare, caffeine helps reduce signs of aging, fights cellulite, and can even help with hair loss. It also protects the skin because it works as an antioxidant and can boost the effect of sunscreens by helping block harmful UV rays more effectively. (Blanco-Llamero et al., 2024) 

Antioxidant effects help protect the body’s cells from damage caused by harmful molecules called free radicals. Antioxidants also help improve blood flow, support new blood vessel growth, and boost cell activity. Some research even suggests that caffeine may block an enzyme called 5-α-reductase, which is involved in hair loss, specifically androgenetic alopecia. (Szendzielorz and Spiewak, 2025)

As new hair cells are produced at the hair bulb, old cells are pushed out through the skin’s surface about six inches a year. 50-100 hairs fall daily is average. This is called a natural occurrence. But when the quantity of hair falls increases and comparatively new hair growth decreases, your hair thins, which is called Hair fall.  

Hair loss can affect how people feel about themselves. It often leads to emotional problems like stress, anxiety, low self-confidence and even depression. Many people feel less like themselves when they lose hair, which can seriously lower their quality of life. 

The most common hair loss is called androgenetic alopecia (AGA). This type of hair loss happens primarily due to aging and genes. About 50% of men will experience it by age 50, and about 40% of women by age 70. In men, it's linked to male hormones called androgens. In women, the hormone link is still being studied, and the condition is often called female pattern hair loss.

To understand hair loss, it's helpful to know how hair grows. Each hair goes through three stages: 

• Anagen (growth stage) – lasts 2 to 7 years. 

• Catagen (transition stage) – a short time (2- 3 weeks) when the hair stops growing. 

• Telogen (resting stage) – the hair stays (3- 4 months) in place before falling out and starting a new cycle.

Healthy hair growth depends on how long the anagen stage lasts. Certain natural factors, like IGF-1 (a growth-promoting protein), help keep hair in the growth stage. On the other hand, TGF-β2 pushes hair into the resting stage. So, more IGF-1 and less TGF-β2 means better hair growth. 

In AGA, androgens (like testosterone) get converted into a more potent hormone called DHT (dihydrotestosterone) by an enzyme called 5α-reductase. DHT causes hair follicles (the tiny roots in your scalp) to shrink. This makes the hair thinner, weaker, and grow for shorter periods. Over time, this leads to visible hair thinning and bald spots. (Völker et al., 2020) 

Caffeine is a powerful ingredient that can help reduce hair loss and support growth. Although the exact way it works isn't fully clear, studies have shown that caffeine boosts the activity of cells in hair follicles, helping them grow better. It increases important growth factors like VEGF (Vascular endothelial growth factor) and KGF (Keratinocyte growth factor), which support healthy hair. Caffeine also helps produce more energy, adenosine triphosphate (ATP), in the hair root cells and improves blood flow by widening blood vessels, like how the hair loss treatment minoxidil works. Experiments showed that caffeine keeps hair in the growth phase (anagen) for longer and encourages more active cell division.  

Clinical studies have also proven caffeine can increase hair density and reduce hair loss. In short, caffeine helps hair stay healthy and grow by boosting energy and nutrient flow to the roots. (Kim et al., 2019) 

Caffeine has recently gained attention as a potential remedy for hair loss, especially for androgenetic alopecia (AGA), a common type of hair thinning. It works by blocking enzymes called phosphodiesterases (PDEs), which leads to an increase in a molecule called cAMP inside cells. This boost in cAMP stimulates cell metabolism and growth, helping hair follicles stay active and produce hair for more extended periods. Caffeine also interacts with adenosine pathways in the body, further enhancing cellular activity in the hair roots. 

Additionally, it acts as an antioxidant, protecting hair follicles from damage caused by stress, aging, or environmental factors. 

Clinical trials support the idea that caffeine can be beneficial in managing hair loss, particularly when applied directly to the scalp through specialized products like shampoos and serums. (Szendzielorz and Spiewak, 2025) 

Additionally, studies have shown that topical application of caffeine, such as through shampoos, allows for rapid absorption via hair follicles, especially within the first 20 minutes of use, making it an effective method for delivering treatment directly to the root of the problem. (Bansal, Manchanda and Pandey, 2012)  

Androgenetic alopecia (AGA) is a condition where androgens like testosterone, especially its more potent form DHT, shorten the hair growth phase (anagen) and cause hair follicles to shrink, leading to thinner, shorter hair. (Völker et al., 2020)  

It is the most common form of hair loss in men and women, primarily caused by genetic factors and the hormone dihydrotestosterone (DHT), which is derived from testosterone. DHT binds to receptors in hair follicles, leading to their gradual shrinkage and a noticeable decrease in hair density. This condition often results in emotional distress and reduced quality of life.

Recent research highlights caffeine, a compound commonly found in cosmetics and beverages, as a potential treatment for AGA. Caffeine may counteract the effects of DHT by blocking the enzyme phosphodiesterase (PDE), which increases cell cAMP levels, boosting energy production and stimulating hair follicle cell growth. (Bansal, Manchanda and Pandey, 2012) 

Caffeine has shown promising effects in counteracting this process. Studies found that caffeine, at low concentrations (10–50 μg/mL), can stimulate hair growth, increase the anagen phase, and reverse testosterone-induced damage by promoting IGF-1 (a growth factor) and reducing TGF-β2 (a growth inhibitor). It boosts keratinocyte proliferation, prevents cell death, and protects hair follicles from UV damage.  

Clinical trials with caffeine shampoos and lotions in men and women with AGA or telogen effluvium showed reduced hair loss, improved hair strength and thickness, and high user satisfaction, with no reported side effects. 

In some studies, caffeine was as effective as minoxidil, a common hair loss drug, and even showed better results when used with it. Caffeine penetrates the scalp well, remains in the hair follicle for over 24 hours, and is safe for long-term use, making it a promising natural alternative for managing AGA. (Völker et al., 2020)  

Renowned for its stimulating effects on the nervous and cardiovascular systems, caffeine demonstrates remarkable versatility. It is widely used in various products, from anti-aging cosmetics to pharmaceutical treatments.

Aging is a slow and natural process where small changes build up in our cells over time. These changes appear on our skin and hair as fine lines, wrinkles, and age spots. As we age, our skin becomes thinner, loses moisture, and its natural barrier weakens, making it more sensitive and less able to protect itself. Sun exposure speeds up this process, causing damage like uneven skin tone, rough texture, and deeper wrinkles. Over time, the skin’s ability to repair itself also slows down, making signs of aging more visible. (Saewan, 2022)

Caffeine has become a popular cosmetic ingredient due to its wide range of skin benefits. Its antioxidant, anti-inflammatory & antimicrobial properties help stimulate hair growth, reduce cellulite, and fight signs of aging. As a powerful antioxidant, caffeine neutralizes free radicals—unstable molecules caused by UV radiation and pollution, that can damage skin cells and accelerate aging. This protective action helps maintain skin health, reduce oxidative stress, and prevent premature wrinkles and pigmentation. When applied topically, caffeine improves blood circulation, reduces dark circles through vasoconstriction (narrowing of blood vessels), and smooths fine lines. It enhances the effectiveness of sunscreens, promotes cell repair, and inhibits enzymes like collagenase, elastase, and tyrosinase, which are involved in skin aging and pigmentation. Advanced delivery systems like nanoparticles are used to improve their absorption into deeper skin layers without entering the bloodstream. These features make caffeine a powerful and versatile bioactive compound in modern skincare. (Blanco-Llamero et al., 2024)

Caffeine (1,3,7-trimethylxanthine), an ancient wonder drug, is a natural neurostimulant found in tea, coffee, soft drinks, analgesics, and energy supplements. It offers benefits such as increased alertness, enhanced mood, improved cognitive and physical performance, and a reduced risk of Parkinson’s disease, type 2 diabetes, and certain cancers, such as prostate, breast, and skin cancer. (Zakir and Hassan, 2013)

Caffeine also improves mental alertness, supports pain relief with ibuprofen, and helps with skin and hair care by enhancing circulation and penetrating hair follicles. While safe in moderate amounts (up to 400 mg/day), excessive use can cause anxiety, fatigue, or mood changes. Caffeine is a versatile, generally safe compound with multiple health and cosmetic benefits. (Völker et al., 2020)    

Excessive use can negatively impact several body systems, including cardiovascular, endocrine, and gastrointestinal, and may even lead to hallucinations.

Its unregulated use in energy drinks—often combined with alcohol—has raised health concerns, especially among youth, increasing the risk of alcohol dependence and risky behaviors. Beyond internal health, caffeine also benefits skin and hair care; it helps improve scalp circulation, stimulate hair growth, and reduce hair fall. For skin, it has antioxidant properties that reduce puffiness, protect against UV damage and improve skin texture. (Zakir and Hassan, 2013)

Responsible consumption is key despite these advantages, and awareness about safe caffeine limits is crucial, especially for children and adolescents. 

Clinical uses:

Used alone to treat:

• Somnolence (excessive sleepiness)

• Headaches (including caffeine withdrawal-related)

• Neonatal respiratory depression

• Postprandial hypotension

• Obesity

• Keeps you awake and helps with breathing in some conditions.

• Works mainly by blocking a brain chemical called adenosine.

•  Using it for a long time can make your body get used to it (tolerance (Sawynok, 1995 ) 

Topical uses:

• Reduces fat buildup in skin cells; used in anti-cellulite creams

• Protects skin from UV damage with strong antioxidant properties

• Slows photoaging, helping skin look younger

• Improves blood flow in the skin, giving a healthy glow

• Promotes hair growth by blocking 5-α-reductase (linked to hair loss)

• Easily absorbed through the skin, making it effective in topical use. (Herman & Herman, 2012)

Topical Caffeine and Scalp Irritation:

When applied to the skin or scalp, caffeine can irritate, especially in people with sensitive skin. This may include redness, itching, or mild rashes. Because caffeine is a stimulant, it can also make the scalp more sensitive, mainly when used in high amounts or mixed with potent ingredients. (mhr-admin, 2024)

Effects on Skin Health:

Topical caffeine might slow wound healing because it blocks adenosine, a compound that helps repair tissue. It can also lower collagen production, which keeps skin firm and smooth. This may lead to thinner skin and early signs of aging, like wrinkles. A 2016 study on mice showed a 40% drop in skin thickness after applying caffeine, but more human studies are needed. (Marcus L Elias, 2023)

Caffeine Safety in the Body:

Moderate caffeine intake (up to 400 mg/day) is generally safe for most people and doesn’t raise the risk of heart problems or high blood pressure. However, very high doses—usually from caffeine powders or pills—can be dangerous and even deadly. People with high blood pressure may be more sensitive and could experience temporary spikes. (Visconti M. J., 2020)

• Saewan, N., 2022. Effect of coffee berry extract on anti-aging for skin and hair—In vitro approach. Cosmetics, 9(3), p.66. Click Here 
• Visconti, M.J., Haidari, W. and Feldman, S.R., 2020. Therapeutic use of caffeine in dermatology: A literature review. Journal of Dermatology and Dermatologic Surgery, 24(1), pp.18-24. Click Here 
• Völker, J.M., Koch, N., Becker, M. and Klenk, A., 2020. Caffeine and its pharmacological benefits in the management of androgenetic alopecia: a review. Skin pharmacology and physiology, 33(3), pp.153-169. Click Here

• Amnuaikit, T., Maneenuan, D. and Boonme, P., 2011. Evaluation of caffeine gels on physicochemical characteristics and in vivo efficacy in reducing puffy eyes. Journal of Applied Pharmaceutical Science, (Issue), pp.56-59. Click Here
• Bansal, M., Manchanda, K. and Pandey, S.S., 2012. Role of caffeine in the management of androgenetic alopecia. International journal of trichology, 4(3), pp.185-186. Click Here
• Blanco-Llamero, C., Macário, H.F., Guedes, B.N., Fathi, F., Oliveira, M.B.P. and Souto, E.B., 2024. Bioactives in nutricosmetics: A focus on caffeine from tea to coffee. Cosmetics, 11(5), p.149. Click Here
• Bussoletti, C., Tolaini, M.V. and Celleno, L., 2018. Efficacy of a cosmetic phyto-caffeine shampoo in female androgenetic alopecia. Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Societa Italiana di Dermatologia e Sifilografia, 155(4), pp.492-499. Click Here
• Elias, M.L., Israeli, A.F. and Madan, R., 2023. Caffeine in skincare: Its Role in skin Cancer, sun protection, and cosmetics. Indian Journal of Dermatology, 68(5), pp.546-550. Click Here
• Gupta, A. and Maurya, J.L., 2023. Extraction and Analysis of Caffeine from Various Sources: A Review. International Journal of Research in Engineering and Science (IJRES) ISSN. Click Here
• Herman, A. and Herman, A.P., 2012. Caffeine’s mechanisms of action and its cosmetic use. Skin pharmacology and physiology, 26(1), pp.8-14. Click Here
• Kim, S., Kim, S.N., Jeong, G., Hong, M.J., Lee, Y., Shin, S.H., Park, H., Jung, Y.C., Kim, E.J., Park, B.C. and Kim, H.J., 2019. Efficacy of caffeine in promoting hair growth by enhancing intracellular activity of hair follicles. Korea Journal of Cosmetic Science, 1(1), pp.11-18. Click Here
• MhrClinic., 2024. The negatives of using Caffeine topically for hair loss. Click Here
• Saewan, N., 2022. Effect of coffee berry extract on anti-aging for skin and hair—In vitro approach. Cosmetics, 9(3), p.66. Click Here
• Sawynok, J., 1995. Pharmacological rationale for the clinical use of caffeine. Drugs, 49(1), pp.37-50. Click Here
• Szendzielorz, E. and Spiewak, R., 2025. Caffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology. Molecules, 30(1), p.167. Click Here
• Visconti, M.J., Haidari, W. and Feldman, S.R., 2020. Therapeutic use of caffeine in dermatology: A literature review. Journal of Dermatology and Dermatologic Surgery, 24(1), pp.18-24. Click Here
• Völker, J.M., Koch, N., Becker, M. and Klenk, A., 2020. Caffeine and its pharmacological benefits in the management of androgenetic alopecia: a review. Skin pharmacology and physiology, 33(3), pp.153-169. Click Here
• Zakir, Z. and Hassan, M., 2013. Caffeine (1, 3, 7-trimethylxanthine): the good and the bad: a review. Journal of Public Health and Biological Sciences, 2(4), p.313. Click Here