Blog 58: What motivated us to formulate Alopex Penta
Posted on April 25 2018
Balding has become a ubiquitous problem today. Irrespective of the age or gender, many suffer from excessive hair loss resulting into partial or total baldness. Hair play a vital role in one’s appearance, losing hair can quickly make one look much older than his or her actual age. Hair thinning & balding at a young age is a traumatic experience for anyone. Balding directly impacts one’s self-confidence, affecting both professional & personal life. Depression, irritability, staying disconnected from peers, inability to deal with the challenges of life are often associated with early balding.
The onset of excess hair fall is often overlooked, allowing the problem to become grave. Most of the times, the issue is not addressed seriously till hair thinning or even partial balding is evident & when the problem is addressed at last, often the victim finds himself helpless as nothing seems to work. Seeing yourself getting bald quickly even at a young age can be extremely distressing & is sure to affect one’s life & mental health.
Keya Seth Aromatherapy, the trusted aromatherapy based cosmeceutical brand from Eastern India has always worked to bring natural solutions to people for complete wellbeing. Ms. Keya Seth, an internationally recognized aromatherapist & the founder of the company have been always keen about finding natural treatments to remedy skin, hair & health issues effectively. With the same motto to support people, helplessly suffering from excess hair fall & balding issues, we started research in our state of the art laboratory at Kolkata.
How did we do the research
Profuse knowledge of Ms. Keya Seth about aromatherapy guided us to pick the natural constituents that have been praised for centuries for hair follicle nourishment & hair growth. To this knowledge we added information derived from different researches performed world over & implemented cutting edge technology driven processes to formulate a combination that can halt hair fall. The outcome was effective but not the ultimate, at least for us.
It took one more year for the team of highly noted chemists & researchers, headed by Ms. Keya Seth to come up with the final Alopex Penta formula that championed in-house clinical trials. In 2013, it was finally sent for third party clinical trials confirming with the latest recommendations of the World Medical Association (WMA) & fully complying with the “Schedules of the Drugs and Cosmetics Act”.
The third party clinical trial was performed on 33 subjects from different age groups, suffering from androgenetic alopecia of stage I-2 to I-3 (Ludwig Scale). The study continued for a span of 86 days. The subjects used approx. 5-6ml of the product, 2 times every day for the mentioned span. At the end of the study,
--------- 94% people taking the trial agreed that the formula promotes hair growth
--------- 97% people taking the trial confirmed that the product makes hair stronger & healthier
--------- 100% people taking the trial agreed that the product improves overall appearance of hair
--------- No unfavorable outcome or skin reactions were reported by any of the subjects taking the study.
Depending on this final report of clinical trial, Alopex Penta was launched in the market & within a year it became our best seller.
Details of our research
Let us start with some basic yet most important information about hair, the reason of hair fall & balding as it will help you understand the intricacies of our research even better.
Hair is basically made of a protein named keratin which gives it the characteristic features. Hair grows from a hair follicle rooted on the scalp. Dermal tissue containing a dermal papilla is present at the base of every hair follicle & this dermal papilla contains network of blood vessels that supply oxygen & nutrition to the hair & removes the wastes produced. The dermal papilla is highly sensitive to hormones that affect hair growth.
The lifecycle of a hair involves three stages,
- Anagen: A period of active growth that lasts for 2 to 4 years
- Catagen: The period of break down & change
- Telogen: The resting phase before resumption of growth, it lasts for 2 to 4 months
On average, a person loose anything between 60 and 100 hairs daily & normally all of which are replaced by new hair. If the hair loss is over 100 per day, it exceeds the replacements, which might result into baldness & thinning. Alopecia, colloquially known as baldness, cannot be considered as a disease but a matter of biological dysfunction.
Culprits behind hair fall & Balding
In 95% of all hair loss cases, DHT or Dihydrotestosterone is the major culprit for hair fall & subsequent balding. Testosterone or the male hormone (which is present in both males & females) is converted to DHT by the action of the enzyme 5 alpha reductase.
The DHT thus produced binds to androgenic receptors in hair follicles & this bond triggers cellular processes that force the hair follicles to shrink & shed the normal hair and produce thinner & shorter hair. DHT propels miniaturization of the hair roots & follicles shortening the growth phase of hair & instigating the next hair to grow finer. Sooner or later the miniaturized hair follicles atrophy & die causing permanent hair loss in men.
Human system generates energy (ATP) by burning food or stored starch/fat. These oxidative reactions generate free radicals in the body. Environmental pollution & stress filled lifestyle often triggers generation of more free radicals. These free radicals affect the hair follicles, shrinking the hair roots triggering hair fall. Miniaturization of the hair roots & hair follicles results into growth of finer, shorter hair & sooner the hair follicles die, resulting into permanent hair loss. The effect of free radicals in balding is more evident amongst women as the female body contains more fat, hence the oxidative stress is much higher.
Amino acid deficiency
As already mentioned, hair is primarily made of a protein named keratin. Keratin is composed of 16 different amino acids. Adequate amino acid levels in the body implies that the body can produce optimum amount of keratin to support the growth & health of hair. In addition to that, amino acids also play a vital role in producing red blood cells that supply oxygen & other nutrients to hair follicles. Hence, deficiency of amino acids in the body can lead to serious hair fall & balding.
Vitamin & Mineral deficiency
Vitamin & Mineral deficiency in the body can be a primary reason for hair fall. The role of B vitamins like Biotin in hair health has been proven through scientific studies. Hence vitamin deficiency can directly stall hair growth resulting into hair fall & hair thinning. Iron as well as trace minerals like Molybdenum, Chromium, Manganese etc. play important roles in the nourishment of hair follicles. Deficiency of these elements can trigger serious hair fall, resulting into partial or complete balding. In India, vitamin & mineral deficiency is often the most common reason of hair fall & baldness amongst women.
Hair fall, hair thinning & partial balding due to hormonal imbalance is more common amongst women compared to men. Imbalance of estrogen & progesterone or thyroid problems can trigger serious hair loss & baldness.
The ultimate product – Alopex Penta
Alopex Penta provides a composition to treat androgenetic alopecia in men & female pattern hair loss in women as well as hair thinning disorder, alopecia areata & alopecia totalis. The formula promotes hair growth in the peeled regions. Alopex Penta is a combination mix of essential oils, amino acids, tannic acid & Biotin in aqueous base for local use in an effective quantity directly on the area to be treated.
The uniqueness of Alopex Penta lies in the synergic effect arising from the interaction of its constituent active ingredients. This topical lotion is a universal hair growth enhancer with potent hypertrichotic effects indicated as treatment against male & female hair loss & alopecia.
Key Ingredients of Alopex Penta
A blend of essential oils of:
- Ocimum basilicum
- Eucalyptus globulus
- Cymbopogon citratus
- Rosmarinus officinalis
- Lavandula angustifolia
- Tannic Acid
- Arginine &
- Aqua D.M
Why we used these essential oils in Alopex Penta?
Essential oils, found only in 10% plants, are highly complex mixtures of volatile compounds. Many contain about 20 to 60 different compounds, but the number can extend to even more than 100. Essential oils are fat soluble & hence they easily penetrate the skin. All findings confirm that most essential oils are rapidly absorbed after dermal, oral or pulmonary administration & cross the blood brain barrier to interact with receptors in the Central Nervous System (CNS) which positively affect relevant biological functions like sleep, digestion, mental relaxation etc.
The most important volatile compounds present in different essential oils used in Alopex Penta are as follows,
- Ocimum basilicum – alpha-Pinene, Comphenes beta Pinene, Myrcene, Limonene, Cis-ocimene, Linalool, Methyl chavicol etc.
- Eucalyptus globulus – 1,8 Cineole
- Cymbopogon citratus -- Limonene
- Rosmarinus officinalis – Camphor, 1,8 Cineole, Verbenone
- Lavandula angustifolia – Linalool & Linalyl acetate
It has been observed through multiple researches that these essential oils inhibit the reduction reaction that converts Testosterone into Dihydrotestosterone (DHT), which is one of the primary reasons for both male & female pattern baldness. So, if your hair loss & balding is triggered by DHT, these essential oils can be most effective to control DHT production without any side effects.
Moreover, the active volatile compounds present in these essential oils hold magical abilities to fight free radicals that work as the second most common reason of balding in Men & the most common cause behind hair loss in women.
The three amino acids in Alopex Penta
As already mentioned, amino acids are the building blocks of the protein keratin which makes the hair strands. The 3 amino acids, Cystine, Methionine & Arginine infused in alopex penta help to prevent balding & stimulate fresh hair growth in more than one ways,
Cystine: it is a non-essential amino acid that has been proven to stimulate hair re growth and fight hair loss. Nearly 10 to 14% of our skin and hair is formed of this amino acid. Cystine in our body is formed by disulphide bonding of two cystine molecules. This dual bonding of amino acids in cystine provides strength to the hair shafts. Besides this, amino acids are also known to improve the immunity system of body to fight any kind of infections that might trigger hair fall.
Methionine: it is another essential amino acid for hair growth. It is a strong anti-oxidant and a warehouse of Sulphur. A key ingredient to thwart hair disorder. Methionine is a good lipotropic as it helps in breaking down fat and prevents fat accumulation in arteries and specific body area. This functionality of Methionine increases blood supply to the hair follicles and scalp. This further leads to hair growth.
Arginine: the effect of arginine on hair growth is phenomenal. Being a precursor of nitric oxide, this amino acid is vital for healthy hair growth. Arginine instigates the level of nitrogen oxide in body which then stimulates the potassium opening of the cells. This results in increased supply of blood to the hair roots, thereby promoting hair growth.
The other two active ingredients present in Alopex Penta are Biotin & Tannic Acid. Check out how these two prevents balding, triggering fresh hair growth,
1. Biotin: Biotin, a B vitamin, possesses rejuvenating abilities that help in the production of new body cells. Biotin helps in preventing hair loss by rejuvenating both the hair follicles and scalp. Biotin supports hair growth through metabolic functions. Keratin is the building block of hair follicles and its formed from several amino acids. Biotin play its role in breaking down the dietary proteins into different amino acids which are required for the formation of Keratin. Increasing Keratin production in the body promotes the production of healthy hair follicles. Biotin also prevents hair dryness and improves the elasticity of hair cortex which stops the splitting and breakage of hair strands.2. Tannic acid: Tannic acid contains poly phenols, which is a powerful anti-oxidant and it inhibits oxidative damage of the hair follicles and thus stops hair fall.
Alopex Penta is a scientifically proven effective treatment for hair loss, hair thinning & baldness. However, the features of this hair growth enhancer go even beyond its effectiveness in inducing fresh hair growth in peeled regions. The formula is 100% safe for use by every adult & has no side effects. It is completely non-oily & non-sticky, which makes it most feasible for regular use.